Cargando…

Mutagenesis of tyrosine and di-leucine motifs in the HIV-1 envelope cytoplasmic domain results in a loss of Env-mediated fusion and infectivity

BACKGROUND: The gp41 component of the Human Immunodeficiency Virus (HIV) envelope glycoprotein (Env) contains a long cytoplasmic domain (CD) with multiple highly conserved tyrosine (Y) and dileucine (LL) motifs. Studies suggest that the motifs distal to major endocytosis motif (Y(712)HRL), located a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bhakta, Sushma J, Shang, Liang, Prince, Jessica L, Claiborne, Daniel T, Hunter, Eric
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3117779/ https://www.ncbi.nlm.nih.gov/pubmed/21569545 http://dx.doi.org/10.1186/1742-4690-8-37

Ejemplares similares

Mutagenesis of the di-leucine motif in the cytoplasmic tail of newcastle disease virus fusion protein modulates the viral fusion ability and pathogenesis
por: Teng, Qingyuan, et al.
Publicado: (2023)

The conserved dileucine- and tyrosine-based motifs in MLV and MPMV envelope glycoproteins are both important to regulate a common Env intracellular trafficking
por: Blot, Vincent, et al.
Publicado: (2006)

Two Di-Leucine Motifs Regulate Trafficking of Mucolipin-1 to Lysosomes
por: Vergarajauregui, Silvia, et al.
Publicado: (2006)

Syntaxin 8 has two functionally distinct di-leucine-based motifs
por: Kasai, Kazuo, et al.
Publicado: (2007)

Two di-leucine motifs regulate trafficking and function of mouse ASIC2a
por: Wu, Junjun, et al.
Publicado: (2016)

Protein targeting by tyrosine- and di-leucine-based signals: evidence for distinct saturable components
Publicado: (1996)

The role of polyproline motifs in the histidine kinase EnvZ
por: Motz, Magdalena, et al.
Publicado: (2018)

Role of the long cytoplasmic domain of the SIV Env glycoprotein in early and late stages of infection
por: Vzorov, Andrei N, et al.
Publicado: (2007)

NucEnvDB: A Database of Nuclear Envelope Proteins and Their Interactions
por: Baltoumas, Fotis A., et al.
Publicado: (2023)

Reassessment of the capacity of the HIV-1 Env cytoplasmic domain to trigger NF-κB activation
por: Beraud, Cyprien, et al.
Publicado: (2018)

Turning of the receptor-binding domains opens up the murine leukaemia virus Env for membrane fusion
por: Wu, Shang-Rung, et al.
Publicado: (2008)

Leucine-Rich Repeat (LRR) Domains Containing Intervening Motifs in Plants
por: Matsushima, Norio, et al.
Publicado: (2012)

Inside the Envelope: Endogenous Retrovirus-K Env as a Biomarker and Therapeutic Target
por: Nadeau, Marie-Josée, et al.
Publicado: (2015)

Endocytic Motif on a Biotin-Tagged HIV-1 Env Modulates the Co-Transfer of Env and Gag during Cell-to-Cell Transmission
por: Barría, María Inés, et al.
Publicado: (2021)

Structure of the Receptor Binding Domain of EnvP(b)1, an Endogenous Retroviral Envelope Protein Expressed in Human Tissues
por: McCarthy, Kevin R., et al.
Publicado: (2020)

HSV-1 Cytoplasmic Envelopment and Egress
por: Ahmad, Imran, et al.
Publicado: (2020)

C-Terminal Di-leucine Motif of Dopamine D(1) Receptor Plays an Important Role in Its Plasma Membrane Trafficking
por: Guo, Yan, et al.
Publicado: (2011)

Site-directed mutagenesis reveals a unique requirement for tyrosine residues in IL-7Rα and TSLPR cytoplasmic domains in TSLP-dependent cell proliferation
por: Zhong, Jun, et al.
Publicado: (2010)

Envés
por: Amara, Luigi, 1971-
Publicado: (2003)

HIV-2 Neutralization Sensitivity in Relation to Co-Receptor Entry Pathways and Env Motifs
por: Szojka, Zsófia Ilona, et al.
Publicado: (2022)

The targeting of Lamp1 to lysosomes is dependent on the spacing of its cytoplasmic tail tyrosine sorting motif relative to the membrane
Publicado: (1996)

Study of the HIV-2 Env Cytoplasmic Tail Variability and Its Impact on Tat, Rev and Nef
por: Bakouche, Nordine, et al.
Publicado: (2013)

Acidic Di-leucine Motif Essential for AP-3–dependent Sorting and Restriction of the Functional Specificity of the Vam3p Vacuolar t-SNARE
por: Darsow, Tamara, et al.
Publicado: (1998)

A Novel Di-Leucine Motif at the N-Terminus of Human Organic Solute Transporter Beta Is Essential for Protein Association and Membrane Localization
por: Xu, Shuhua, et al.
Publicado: (2016)

Membrane Fusion and Cell Entry of XMRV Are pH-Independent and Modulated by the Envelope Glycoprotein's Cytoplasmic Tail
por: Côté, Marceline, et al.
Publicado: (2012)

Inhibition of β(2)Integrin–Mediated Leukocyte Cell Adhesion by Leucine–Leucine–Glycine Motif–Containing Peptides
por: Koivunen, Erkki, et al.
Publicado: (2001)

The role of cell-envelope synthesis for envelope growth and cytoplasmic density in Bacillus subtilis
por: Kitahara, Yuki, et al.
Publicado: (2022)

Receptor-Induced Thiolate Couples Env Activation to Retrovirus Fusion and Infection
por: Smith, Jason G, et al.
Publicado: (2007)

Cryptic protein-protein interaction motifs in the cytoplasmic domain of MHCI proteins
por: Frietze, Karla K., et al.
Publicado: (2016)

The Polarization of the G-Protein Activated Potassium Channel GIRK5 to the Vegetal Pole of Xenopus laevis Oocytes Is Driven by a Di-Leucine Motif
por: Díaz-Bello, Beatriz, et al.
Publicado: (2013)

ALV-J GP37 Molecular Analysis Reveals Novel Virus-Adapted Sites and Three Tyrosine-Based Env Species
por: Ye, Jianqiang, et al.
Publicado: (2015)

THE NUCLEAR ENVELOPE : ITS STRUCTURE AND RELATION TO CYTOPLASMIC MEMBRANES
por: Watson, Michael L.
Publicado: (1955)

The frantic play of the concealed HIV envelope cytoplasmic tail
por: da Silva, Eveline Santos, et al.
Publicado: (2013)

Characterization of BIV Env core: Implication for mechanism of BIV-mediated cell fusion
por: Li, Shu, et al.
Publicado: (2005)

New insights into the phosphorylation of the threonine motif of the β1 integrin cytoplasmic domain
por: Böttcher, Ralph T, et al.
Publicado: (2022)

A nested leucine rich repeat (LRR) domain: The precursor of LRRs is a ten or eleven residue motif
por: Matsushima, Norio, et al.
Publicado: (2010)

Mutagenesis analysis of T380R mutation in the envelope protein of yellow fever virus
por: Huang, Yan-Jang S, et al.
Publicado: (2014)

The C-terminal tail of HIV-1 envelope: a unique role for conserved LLP arginines in Env functional properties
por: Kuhlmann, A, et al.
Publicado: (2012)

Generation of H9 T-cells stably expressing a membrane-bound form of the cytoplasmic tail of the Env-glycoprotein: lack of transcomplementation of defective HIV-1 virions encoding C-terminally truncated Env
por: Holtkotte, Denise, et al.
Publicado: (2006)

Fusion of Enveloped Viruses in Endosomes
por: White, Judith M., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_30r6nkaa8qm5oifdq0f8ccf04l