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Ribosomal Protein S6 Kinase (RSK)-2 as a central effector molecule in RON receptor tyrosine kinase mediated epithelial to mesenchymal transition induced by macrophage-stimulating protein

BACKGROUND: Epithelial to mesenchymal transition (EMT) occurs during cancer cell invasion and malignant metastasis. Features of EMT include spindle-like cell morphology, loss of epithelial cellular markers and gain of mesenchymal phenotype. Activation of the RON receptor tyrosine kinase by macrophag...

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Detalles Bibliográficos
Autores principales: Ma, Qi, Guin, Sunny, Padhye, Snehal S, Zhou, Yong-Qing, Zhang, Rui-Wen, Wang, Ming-Hai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3117816/
https://www.ncbi.nlm.nih.gov/pubmed/21619683
http://dx.doi.org/10.1186/1476-4598-10-66