Expression of Fbxo7 in Haematopoietic Progenitor Cells Cooperates with p53 Loss to Promote Lymphomagenesis

Fbxo7 is an unusual F box protein that augments D-type cyclin complex formation with Cdk6, but not Cdk4 or Cdk2, and its over-expression has been demonstrated to transform immortalised fibroblasts in a Cdk6-dependent manner. Here we present new evidence in vitro and in vivo on the oncogenic potentia...

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Detalles Bibliográficos
Autores principales: Lomonosov, Mikhail, Meziane, El Kahina, Ye, Hongtao, Nelson, David E., Randle, Suzanne J., Laman, Heike
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3117880/
https://www.ncbi.nlm.nih.gov/pubmed/21695055
http://dx.doi.org/10.1371/journal.pone.0021165

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3117880/
https://www.ncbi.nlm.nih.gov/pubmed/21695055
http://dx.doi.org/10.1371/journal.pone.0021165

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