Determination of the Proteolytic Cleavage Sites of the Amyloid Precursor-Like Protein 2 by the Proteases ADAM10, BACE1 and γ-Secretase

Regulated intramembrane proteolysis of the amyloid precursor protein (APP) by the protease activities α-, β- and γ-secretase controls the generation of the neurotoxic amyloid β peptide. APLP2, the amyloid precursor-like protein 2, is a homolog of APP, which shows functional overlap with APP, but lac...

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Detalles Bibliográficos
Autores principales: Hogl, Sebastian, Kuhn, Peer-Hendrik, Colombo, Alessio, Lichtenthaler, Stefan F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3117885/
https://www.ncbi.nlm.nih.gov/pubmed/21695060
http://dx.doi.org/10.1371/journal.pone.0021337

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3117885/
https://www.ncbi.nlm.nih.gov/pubmed/21695060
http://dx.doi.org/10.1371/journal.pone.0021337

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