Analysis of the anti-tumor effect of cetuximab using protein kinetics and mouse xenograft models

BACKGROUND: The binding of EGFR and its ligands leads to autophosphorylation of receptor tyrosine kinase as well as subsequent activation of signal transduction pathways that are involved in regulating cellular proliferation, differentiation, and survival. An EGFR inhibitor, cetuximab binds to EGFR...

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Detalles Bibliográficos
Autores principales: Matsuo, Teppei, Nishizuka, Satoshi S, Ishida, Kazushige, Iwaya, Takeshi, Ikeda, Miyuki, Wakabayashi, Go
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3118158/
https://www.ncbi.nlm.nih.gov/pubmed/21554739
http://dx.doi.org/10.1186/1756-0500-4-140

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3118158/
https://www.ncbi.nlm.nih.gov/pubmed/21554739
http://dx.doi.org/10.1186/1756-0500-4-140

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