Applying neutral drift to the directed molecular evolution of a β-glucuronidase into a β-galactosidase: Two different evolutionary pathways lead to the same variant

BACKGROUND: Directed protein evolution has been used to modify protein activity and research has been carried out to enhance the production of high quality mutant libraries. Many theoretical approaches suggest that allowing a population to undergo neutral selection may be valuable in directed evolut...

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Detalles Bibliográficos
Autores principales: Smith, Wendy S, Hale, Jennifer R, Neylon, Cameron
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3118342/
https://www.ncbi.nlm.nih.gov/pubmed/21548964
http://dx.doi.org/10.1186/1756-0500-4-138

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3118342/
https://www.ncbi.nlm.nih.gov/pubmed/21548964
http://dx.doi.org/10.1186/1756-0500-4-138

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