Second generation sequencing allows for mtDNA mixture deconvolution and high resolution detection of heteroplasmy

AIM: To use parallel array pyrosequencing to deconvolute mixtures of mitochondrial DNA (mtDNA) sequence and provide high resolution analysis of mtDNA heteroplasmy. METHODS: The hypervariable segment 1 (HV1) of the mtDNA control region was analyzed from 30 individuals using the 454 GS Junior instrume...

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Detalles Bibliográficos
Autores principales: Holland, Mitchell M., McQuillan, Megan R., O’Hanlon, Katherine A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Croatian Medical Schools 2011
Materias:
Forensic Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3118725/
https://www.ncbi.nlm.nih.gov/pubmed/21674826
http://dx.doi.org/10.3325/cmj.2011.52.299

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3118725/
https://www.ncbi.nlm.nih.gov/pubmed/21674826
http://dx.doi.org/10.3325/cmj.2011.52.299

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