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Urothelial antigen-specific CD4(+) T cells function as direct effector cells and induce bladder autoimmune inflammation independent of CD8(+) T cells

The role of CD4(+) T cells in bladder autoimmune inflammation has not been identified due to the lack of a proper animal model. We investigated CD4(+) T cell responses to bladder urothelial ovalbumin (OVA), a model self-antigen (Ag), in transgenic URO-OVA mice. The expression of bladder urothelial O...

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Detalles Bibliográficos
Autores principales: Liu, Wujiang, Chen, Xiaohong, Evanoff, David P., Luo, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3118865/
https://www.ncbi.nlm.nih.gov/pubmed/21270773
http://dx.doi.org/10.1038/mi.2010.90

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