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Structure and Mechanism of the Diterpene Cyclase ent-Copalyl Diphosphate Synthase

The structure of ent-copalyl diphosphate synthase (CPS) reveals three α-helical domains (α, β, γ), as also observed in the related diterpene cyclase taxadiene synthase. However, active sites are located at the interface of the βγ domains in CPS but exclusively in the α domain of taxadiene synthase....

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Detalles Bibliográficos
Autores principales: Köksal, Mustafa, Hu, Huayou, Coates, Robert M., Peters, Reuben J., Christianson, David W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3118866/
https://www.ncbi.nlm.nih.gov/pubmed/21602811
http://dx.doi.org/10.1038/nchembio.578