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High-Resolution X-Ray Structure of the Trimeric Scar/WAVE-Complex Precursor Brk1
The Scar/WAVE-complex links upstream Rho-GTPase signaling to the activation of the conserved Arp2/3-complex. Scar/WAVE-induced and Arp2/3-complex-mediated actin nucleation is crucial for actin assembly in protruding lamellipodia to drive cell migration. The heteropentameric Scar/WAVE-complex is comp...
Autores principales: | Linkner, Joern, Witte, Gregor, Stradal, Theresia, Curth, Ute, Faix, Jan |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3119050/ https://www.ncbi.nlm.nih.gov/pubmed/21701600 http://dx.doi.org/10.1371/journal.pone.0021327 |
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