Pharmacological Blockade of Serotonin 5-HT(7) Receptor Reverses Working Memory Deficits in Rats by Normalizing Cortical Glutamate Neurotransmission

The role of 5-HT(7) receptor has been demonstrated in various animal models of mood disorders; however its function in cognition remains largely speculative. This study evaluates the effects of SB-269970, a selective 5-HT(7) antagonist, in a translational model of working memory deficit and investig...

Descripción completa

Detalles Bibliográficos
Autores principales: Bonaventure, Pascal, Aluisio, Leah, Shoblock, James, Boggs, Jamin D., Fraser, Ian C., Lord, Brian, Lovenberg, Timothy W., Galici, Ruggero
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3119073/
https://www.ncbi.nlm.nih.gov/pubmed/21701689
http://dx.doi.org/10.1371/journal.pone.0020210

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3119073/
https://www.ncbi.nlm.nih.gov/pubmed/21701689
http://dx.doi.org/10.1371/journal.pone.0020210

Ejemplares similares