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Modulation of Myocardial Mitochondrial Mechanisms during Severe Polymicrobial Sepsis in the Rat

BACKGROUND: We tested the hypothesis that 5-Hydroxydecanoic acid (5HD), a putative mitoK(ATP) channel blocker, will reverse sepsis-induced cardiodynamic and adult rat ventricular myocyte (ARVM) contractile dysfunction, restore mitochondrial membrane permeability alterations and improve survival. MET...

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Detalles Bibliográficos
Autores principales:	Chopra, Mani, Golden, Honey B., Mullapudi, Srinivas, Dowhan, William, Dostal, David E., Sharma, Avadhesh C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3119671/ https://www.ncbi.nlm.nih.gov/pubmed/21712982 http://dx.doi.org/10.1371/journal.pone.0021285

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