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Efficient Allele-Specific Targeting of LRRK2 R1441 Mutations Mediated by RNAi
Since RNA interference (RNAi) has the potential to discriminate between single nucleotide changes, there is growing interest in the use of RNAi as a promising therapeutical approach to target dominant disease-associated alleles. Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene have been li...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3119704/ https://www.ncbi.nlm.nih.gov/pubmed/21712955 http://dx.doi.org/10.1371/journal.pone.0021352 |