Oxidation of the cysteine-rich regions of parkin perturbs its E3 ligase activity and contributes to protein aggregation

BACKGROUND: Accumulation of aberrant proteins to form Lewy bodies (LBs) is a hallmark of Parkinson's disease (PD). Ubiquitination-mediated degradation of aberrant, misfolded proteins is critical for maintaining normal cell function. Emerging evidence suggests that oxidative/nitrosative stress c...

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Detalles Bibliográficos
Autores principales: Meng, Fanjun, Yao, Dongdong, Shi, Yang, Kabakoff, Jonathan, Wu, Wei, Reicher, Joshua, Ma, Yuliang, Moosmann, Bernd, Masliah, Eliezer, Lipton, Stuart A, Gu, Zezong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3120712/
https://www.ncbi.nlm.nih.gov/pubmed/21595948
http://dx.doi.org/10.1186/1750-1326-6-34

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3120712/
https://www.ncbi.nlm.nih.gov/pubmed/21595948
http://dx.doi.org/10.1186/1750-1326-6-34

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