Cargando…

Oxidation of the cysteine-rich regions of parkin perturbs its E3 ligase activity and contributes to protein aggregation

BACKGROUND: Accumulation of aberrant proteins to form Lewy bodies (LBs) is a hallmark of Parkinson's disease (PD). Ubiquitination-mediated degradation of aberrant, misfolded proteins is critical for maintaining normal cell function. Emerging evidence suggests that oxidative/nitrosative stress c...

Descripción completa

Detalles Bibliográficos
Autores principales:	Meng, Fanjun, Yao, Dongdong, Shi, Yang, Kabakoff, Jonathan, Wu, Wei, Reicher, Joshua, Ma, Yuliang, Moosmann, Bernd, Masliah, Eliezer, Lipton, Stuart A, Gu, Zezong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3120712/ https://www.ncbi.nlm.nih.gov/pubmed/21595948 http://dx.doi.org/10.1186/1750-1326-6-34

Ejemplares similares

S-Nitrosylation of parkin as a novel regulator of p53-mediated neuronal cell death in sporadic Parkinson’s disease
por: Sunico, Carmen R, et al.
Publicado: (2013)

Structure of the human Parkin ligase domain in an autoinhibited state
por: Wauer, Tobias, et al.
Publicado: (2013)

PARKIN ubiquitin ligase mediates resistance to intracellular pathogens
por: Manzanillo, Paolo S., et al.
Publicado: (2013)

Probing the Role of Cysteine Thiyl Radicals in Biology: Eminently Dangerous, Difficult to Scavenge
por: Moosmann, Bernd, et al.
Publicado: (2022)

Mdm2 enhances ligase activity of parkin and facilitates mitophagy
por: Kook, Seunghyi, et al.
Publicado: (2020)

Structure and function of Parkin E3 ubiquitin ligase reveals aspects of RING and HECT ligases
por: Riley, B.E., et al.
Publicado: (2013)

Parkin Precipitates on Mitochondria via Aggregation and Autoubiquitination
por: Ardah, Mustafa T., et al.
Publicado: (2023)

Molecular dynamics simulations of human E3 ubiquitin ligase Parkin
por: Qiu, Shi, et al.
Publicado: (2017)

The Relationship between Parkin and Protein Aggregation in Neurodegenerative Diseases
por: Khandelwal, Preeti J., et al.
Publicado: (2010)

Disruption of the autoinhibited state primes the E3 ligase parkin for activation and catalysis
por: Kumar, Atul, et al.
Publicado: (2015)

Probes of Ubiquitin E3 ligases distinguish different stages of Parkin activation
por: Pao, Kuan-Chuan, et al.
Publicado: (2016)

Discovery of small-molecule positive allosteric modulators of Parkin E3 ligase
por: Shlevkov, Evgeny, et al.
Publicado: (2021)

Identification & characterization of leucine-rich repeat kinase 2 & parkin RBR E3 ubiquitin protein ligase variants in patients with Parkinson's disease
por: Halder, Tamali, et al.
Publicado: (2020)

Phosphorylation of Parkin at Serine65 is essential for activation: elaboration of a Miro1 substrate-based assay of Parkin E3 ligase activity
por: Kazlauskaite, Agne, et al.
Publicado: (2014)

PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity
por: Kane, Lesley A., et al.
Publicado: (2014)

Exercise induced upregulation of glutamate-cysteine ligase catalytic subunit and glutamate-cysteine ligase modifier subunit gene expression in Thoroughbred horses
por: Park, Jeong-Woong, et al.
Publicado: (2017)

Oral N-Acetyl-Cysteine Attenuates Loss of Dopaminergic Terminals in α-Synuclein Overexpressing Mice
por: Clark, Joanne, et al.
Publicado: (2010)

Covalent ISG15 conjugation positively regulates the ubiquitin E3 ligase activity of parkin
por: Im, Eunju, et al.
Publicado: (2016)

OaAEP1 Ligase-Assisted Chemoenzymatic Synthesis of Full Cysteine-Rich Metal-Binding Cyanobacterial Metallothionein SmtA
por: Antonenko, Anastasiia, et al.
Publicado: (2023)

Tuberous sclerosis complex neuropathology requires glutamate-cysteine ligase
por: Malik, Anna R., et al.
Publicado: (2015)

Cellular internalization of alpha-synuclein aggregates by cell surface heparan sulfate depends on aggregate conformation and cell type
por: Ihse, Elisabet, et al.
Publicado: (2017)

Lysine 27 Ubiquitination of the Mitochondrial Transport Protein Miro Is Dependent on Serine 65 of the Parkin Ubiquitin Ligase
por: Birsa, Nicol, et al.
Publicado: (2014)

Parkin-phosphoubiquitin complex reveals a cryptic ubiquitin binding site required for RBR ligase activity
por: Kumar, Atul, et al.
Publicado: (2017)

Resveratrol affects the expression of glutamate cysteine ligase in the kidneys of aged rats
por: YUAN, JIANGSHUI, et al.
Publicado: (2014)

Structural Basis of Cysteine Ligase MshC Inhibition by Cysteinyl-Sulfonamides
por: Pang, Luping, et al.
Publicado: (2022)

Phosphorylation by PINK1 Releases the UBL Domain and Initializes the Conformational Opening of the E3 Ubiquitin Ligase Parkin
por: Caulfield, Thomas R., et al.
Publicado: (2014)

Neuronal Proteomic Analysis of the Ubiquitinated Substrates of the Disease-Linked E3 Ligases Parkin and Ube3a
por: Martinez, Aitor, et al.
Publicado: (2018)

PICK1 inhibits the E3 ubiquitin ligase activity of Parkin and reduces its neuronal protective effect
por: He, Jing, et al.
Publicado: (2018)

Impact of altered phosphorylation on loss of function of juvenile Parkinsonism–associated genetic variants of the E3 ligase parkin
por: Aguirre, Jacob D., et al.
Publicado: (2018)

Small, N-Terminal Tags Activate Parkin E3 Ubiquitin Ligase Activity by Disrupting Its Autoinhibited Conformation
por: Burchell, Lynn, et al.
Publicado: (2012)

A substrate-trapping strategy to find E3 ubiquitin ligase substrates identifies Parkin and TRIM28 targets
por: Watanabe, Masashi, et al.
Publicado: (2020)

Glutamate-cysteine ligase catalytic subunit is associated with cisplatin resistance in lung adenocarcinoma
por: Hiyama, Noriko, et al.
Publicado: (2018)

Glutamate-Cysteine Ligase Catalytic Subunit Attenuated Hepatitis C Virus-Related Liver Fibrosis and Suppressed Endoplasmic Reticulum Stress
por: Fu, Na, et al.
Publicado: (2020)

Parkin Bequest
Publicado: (1891)

Disease-causing mutations in Parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy
por: Lee, Joo-Yong, et al.
Publicado: (2010)

Evolvability and Neurodegenerative Disease: Antagonistic Pleiotropy Phenomena Derived from Amyloid Aggregates
por: Hashimoto, Makoto, et al.
Publicado: (2018)

PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65
por: Kondapalli, Chandana, et al.
Publicado: (2012)

The PINK1 kinase-driven ubiquitin ligase Parkin promotes mitochondrial protein import through the presequence pathway in living cells
por: Jacoupy, M., et al.
Publicado: (2019)

PINK1-Mediated Phosphorylation of Parkin Boosts Parkin Activity in Drosophila
por: Shiba-Fukushima, Kahori, et al.
Publicado: (2014)

Exciton dynamics in perturbed vibronic molecular aggregates
por: Brüning, C., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_3v4chorktioqf5b1lunmnoqp5p