HMGB1 Attenuates Cardiac Remodelling in the Failing Heart via Enhanced Cardiac Regeneration and miR-206-Mediated Inhibition of TIMP-3

AIMS: HMGB1 injection into the mouse heart, acutely after myocardial infarction (MI), improves left ventricular (LV) function and prevents remodeling. Here, we examined the effect of HMGB1 in chronically failing hearts. METHODS AND RESULTS: Adult C57 BL16 female mice underwent coronary artery ligati...

Descripción completa

Detalles Bibliográficos
Autores principales: Limana, Federica, Esposito, Grazia, D'Arcangelo, Daniela, Di Carlo, Anna, Romani, Sveva, Melillo, Guido, Mangoni, Antonella, Bertolami, Chiara, Pompilio, Giulio, Germani, Antonia, Capogrossi, Maurizio C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3120764/
https://www.ncbi.nlm.nih.gov/pubmed/21731608
http://dx.doi.org/10.1371/journal.pone.0019845

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3120764/
https://www.ncbi.nlm.nih.gov/pubmed/21731608
http://dx.doi.org/10.1371/journal.pone.0019845

Ejemplares similares