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The HPV-16 E7 oncoprotein induces centriole multiplication through deregulation of Polo-like kinase 4 expression

BACKGROUND: Infection with high-risk human papillomaviruses (HPVs) such as HPV-16 is intimately associated with squamous cell carcinomas (SCCs) of the anogenital tract and a subset of oropharyngeal carcinomas. Such lesions, including pre-invasive precursors, frequently show multipolar mitoses and an...

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Detalles Bibliográficos
Autores principales: Korzeniewski, Nina, Treat, Benjamin, Duensing, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3120798/
https://www.ncbi.nlm.nih.gov/pubmed/21609466
http://dx.doi.org/10.1186/1476-4598-10-61