Selective p38α mitogen-activated protein kinase inhibitor attenuates lung inflammation and fibrosis in IL-13 transgenic mouse model of asthma

p38 Mitogen-activated protein kinase (MAPK) plays a critical role in the activation of inflammatory cells. We investigated the anti-inflammatory effects of a p38α-selective MAPK inhibitor (SD-282) in a mouse transgenic (CC10:IL-13) asthma model. The CC-10-driven over-expression of IL-13 in the mouse...

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Detalles Bibliográficos
Autores principales: Ma, Jing Ying, Medicherla, Satyanarayana, Kerr, Irene, Mangadu, Ruban, Protter, Andrew A, Higgins, Linda S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2008
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3121334/
https://www.ncbi.nlm.nih.gov/pubmed/21436983

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3121334/
https://www.ncbi.nlm.nih.gov/pubmed/21436983

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