Klotho Depletion Contributes to Increased Inflammation in Kidney of the db/db Mouse Model of Diabetes via RelA (Serine)(536) Phosphorylation

OBJECTIVE: Klotho is an antiaging hormone present in the kidney that extends the lifespan, regulates kidney function, and modulates cellular responses to oxidative stress. We investigated whether Klotho levels and signaling modulate inflammation in diabetic kidneys. RESEARCH DESIGN AND METHODS: Rena...

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Detalles Bibliográficos
Autores principales: Zhao, Yanhua, Banerjee, Srijita, Dey, Nilay, LeJeune, Wanda S., Sarkar, Partha S., Brobey, Reynolds, Rosenblatt, Kevin P., Tilton, Ronald G., Choudhary, Sanjeev
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2011
Materias:
Signal Transduction
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3121423/
https://www.ncbi.nlm.nih.gov/pubmed/21593200
http://dx.doi.org/10.2337/db10-1262

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3121423/
https://www.ncbi.nlm.nih.gov/pubmed/21593200
http://dx.doi.org/10.2337/db10-1262

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