Glycation of LDL by Methylglyoxal Increases Arterial Atherogenicity: A Possible Contributor to Increased Risk of Cardiovascular Disease in Diabetes

OBJECTIVE: To study whether modification of LDL by methylglyoxal (MG), a potent arginine-directed glycating agent that is increased in diabetes, is associated with increased atherogenicity. RESEARCH DESIGN AND METHODS: Human LDL was isolated and modified by MG in vitro to minimal extent (MG(min)-LDL...

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Detalles Bibliográficos
Autores principales: Rabbani, Naila, Godfrey, Lisa, Xue, Mingzhan, Shaheen, Fozia, Geoffrion, Michèle, Milne, Ross, Thornalley, Paul J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2011
Materias:
Complications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3121424/
https://www.ncbi.nlm.nih.gov/pubmed/21617182
http://dx.doi.org/10.2337/db11-0085

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3121424/
https://www.ncbi.nlm.nih.gov/pubmed/21617182
http://dx.doi.org/10.2337/db11-0085

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