The Soluble CTLA-4 Splice Variant Protects From Type 1 Diabetes and Potentiates Regulatory T-Cell Function

OBJECTIVE: CTLA4 gene variation associates with multiple autoimmune disorders, including type 1 diabetes. The CTLA4 susceptibility allele was found to generate decreased levels of mRNA encoding soluble CTLA-4 (sCTLA-4) relative to the full-length isoform, the functional consequence of which is as ye...

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Detalles Bibliográficos
Autores principales: Gerold, Kay D., Zheng, Peilin, Rainbow, Daniel B., Zernecke, Alma, Wicker, Linda S., Kissler, Stephan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2011
Materias:
Immunology and Transplantation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3121435/
https://www.ncbi.nlm.nih.gov/pubmed/21602513
http://dx.doi.org/10.2337/db11-0130

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3121435/
https://www.ncbi.nlm.nih.gov/pubmed/21602513
http://dx.doi.org/10.2337/db11-0130

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