Dexamethasone inhibits the Nox-dependent ROS production via suppression of MKP-1-dependent MAPK pathways in activated microglia

BACKGROUND: Nox-2 (also known as gp91phox), a subunit component of NADPH oxidases, generates reactive oxygen species (ROS). Nox-dependent ROS generation and nitric oxide (NO) release by microglia have been implicated in a variety of diseases in the central nervous system. Dexamethasone (Dex) has bee...

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Detalles Bibliográficos
Autores principales: Huo, Yingqian, Rangarajan, Parakalan, Ling, Eng-Ang, Dheen, S Thameem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3121618/
https://www.ncbi.nlm.nih.gov/pubmed/21615929
http://dx.doi.org/10.1186/1471-2202-12-49

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3121618/
https://www.ncbi.nlm.nih.gov/pubmed/21615929
http://dx.doi.org/10.1186/1471-2202-12-49

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