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Robust Network Topologies for Generating Switch-Like Cellular Responses
Signaling networks that convert graded stimuli into binary, all-or-none cellular responses are critical in processes ranging from cell-cycle control to lineage commitment. To exhaustively enumerate topologies that exhibit this switch-like behavior, we simulated all possible two- and three-component...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2011
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3121696/ https://www.ncbi.nlm.nih.gov/pubmed/21731481 http://dx.doi.org/10.1371/journal.pcbi.1002085 |