Detailed Regulatory Mechanism of the Interaction between ZO-1 PDZ2 and Connexin43 Revealed by MD Simulations

The gap junction protein connexin43 (Cx43) binds to the second PDZ domain of Zonula occludens-1 (ZO-1) through its C-terminal tail, mediating the regulation of gap junction plaque size and dynamics. Biochemical study demonstrated that the very C-terminal 12 residues of Cx43 are necessary and suffici...

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Detalles Bibliográficos
Autores principales: Xiao, Fei, Weng, Jingwei, Fan, Kangnian, Wang, Wenning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3121883/
https://www.ncbi.nlm.nih.gov/pubmed/21731774
http://dx.doi.org/10.1371/journal.pone.0021527

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3121883/
https://www.ncbi.nlm.nih.gov/pubmed/21731774
http://dx.doi.org/10.1371/journal.pone.0021527

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