Cargando…

Phenethyl isothiocyanate exhibits antileukemic activity in vitro and in vivo by inactivation of Akt and activation of JNK pathways

Effects of phenethyl isothiocyanate (PEITC) have been investigated in human leukemia cells (U937, Jurkat, and HL-60) as well as in primary human acute myeloid leukemia (AML) cells in relation to apoptosis and cell signaling events. Exposure of cells to PEITC resulted in pronounced increase in the ac...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gao, N, Budhraja, A, Cheng, S, Liu, E-H, Chen, J, Yang, Z, Chen, D, Zhang, Z, Shi, X
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2011
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3122055/ https://www.ncbi.nlm.nih.gov/pubmed/21472003 http://dx.doi.org/10.1038/cddis.2011.22

Ejemplares similares

3, 3′-Diindolylmethane Exhibits Antileukemic Activity In Vitro and In Vivo through a Akt-Dependent Process
por: Gao, Ning, et al.
Publicado: (2012)

Retraction: 3, 3′-Diindolylmethane Exhibits Antileukemic Activity In Vitro and In Vivo through a Akt-Dependent Process
Publicado: (2020)

Phenethyl isothiocyanate activates leptin signaling and decreases food intake
por: Yagi, Miho, et al.
Publicado: (2018)

Phenethyl Isothiocyanate Inhibits In Vivo Growth of Xenograft Tumors of Human Glioblastoma Cells
por: Chou, Yu-Cheng, et al.
Publicado: (2018)

Antitumor activity of phenethyl isothiocyanate in HER2-positive breast cancer models
por: Gupta, Parul, et al.
Publicado: (2012)

Dietary Isothiocyanates, Sulforaphane and 2-Phenethyl Isothiocyanate, Effectively Impair Vibrio cholerae Virulence
por: Krause, Klaudyna, et al.
Publicado: (2021)

Metformin and phenethyl isothiocyanate combined treatment in vitro is cytotoxic to ovarian cancer cultures
por: Chan, Daniel K, et al.
Publicado: (2012)

Phenethyl Isothiocyanate, a Dual Activator of Transcription Factors NRF2 and HSF1
por: Dayalan Naidu, Sharadha, et al.
Publicado: (2018)

Notch Activation by Phenethyl Isothiocyanate Attenuates Its Inhibitory Effect on Prostate Cancer Cell Migration
por: Kim, Su-Hyeong, et al.
Publicado: (2011)

Phenethyl Isothiocyanate Suppresses the Proinflammatory Cytokines in Human Glioblastoma Cells through the PI3K/Akt/NF-κB Signaling Pathway In Vitro
por: Hsu, Sheng-Yao, et al.
Publicado: (2022)

BAG3 Protein Is Involved in Endothelial Cell Response to Phenethyl Isothiocyanate
por: Franceschelli, Silvia, et al.
Publicado: (2018)

Metastasis of Breast Tumor Cells to Brain Is Suppressed by Phenethyl Isothiocyanate in a Novel In Vivo Metastasis Model
por: Gupta, Parul, et al.
Publicado: (2013)

Phenethyl Isothiocyanate Induces Apoptosis Through ROS Generation and Caspase-3 Activation in Cervical Cancer Cells
por: Shoaib, Shoaib, et al.
Publicado: (2021)

Dietary Phenethyl Isothiocyanate Alters Gene Expression in Human Breast Cancer Cells
por: Moon, Young Jin, et al.
Publicado: (2011)

Nrf2 Knockout Attenuates the Anti-Inflammatory Effects of Phenethyl Isothiocyanate and Curcumin
por: Boyanapalli, Sarandeep S. S., et al.
Publicado: (2014)

Dietary Phenethyl Isothiocyanate Protects Mice from Colitis Associated Colon Cancer
por: Liu, Yi, et al.
Publicado: (2017)

Various modes of action of dietary phytochemicals, sulforaphane and phenethyl isothiocyanate, on pathogenic bacteria
por: Nowicki, Dariusz, et al.
Publicado: (2019)

Phenethyl Isothiocyanate-Containing Carbomer Gel for Use against Squamous Cell Carcinoma
por: Osipitan, Ositomiwa O., et al.
Publicado: (2021)

Silvestrol exhibits significant in vivo and in vitro antileukemic activities and inhibits FLT3 and miR-155 expressions in acute myeloid leukemia
por: Alachkar, Houda, et al.
Publicado: (2013)

Comparison of the Impact of Xanthohumol and Phenethyl Isothiocyanate and Their Combination on Nrf2 and NF-κB Pathways in HepG2 Cells In Vitro and Tumor Burden In Vivo
por: Cykowiak, Marta, et al.
Publicado: (2021)

Comparison of in vitro antileukemic activity of obatoclax and ABT-737
por: Opydo-Chanek, Małgorzata, et al.
Publicado: (2016)

Miltirone exhibits antileukemic activity by ROS-mediated endoplasmic reticulum stress and mitochondrial dysfunction pathways
por: Zhou, Ling, et al.
Publicado: (2016)

Phenethyl Isothiocyanate-Conjugated Chitosan Oligosaccharide Nanophotosensitizers for Photodynamic Treatment of Human Cancer Cells
por: Bae, Inho, et al.
Publicado: (2022)

Reactivation of mutant p53 by a dietary-related compound phenethyl isothiocyanate inhibits tumor growth
por: Aggarwal, M, et al.
Publicado: (2016)

In Vitro Antileukemic Activity of Xanthosoma sagittifolium (Taioba) Leaf Extract
por: Caxito, Marina L. C., et al.
Publicado: (2015)

Induction of Epoxide Hydrolase, Glucuronosyl Transferase, and Sulfotransferase by Phenethyl Isothiocyanate in Male Wistar Albino Rats
por: Abdull Razis, Ahmad Faizal, et al.
Publicado: (2014)

Phenethyl isothiocyanate and paclitaxel synergistically enhanced apoptosis and alpha-tubulin hyperacetylation in breast cancer cells
por: Cang, Shundong, et al.
Publicado: (2014)

Irreversible Inhibition of Glutathione S-Transferase by Phenethyl Isothiocyanate (PEITC), a Dietary Cancer Chemopreventive Phytochemical
por: Kumari, Vandana, et al.
Publicado: (2016)

Phenethyl isothiocyanate induces calcium mobilization and mitochondrial cell death pathway in cholangiocarcinoma KKU-M214 cells
por: Tusskorn, Ornanong, et al.
Publicado: (2013)

Spatholobus suberectus Exhibits Antidiabetic Activity In Vitro and In Vivo through Activation of AKT-AMPK Pathway
por: Zhao, Peijun, et al.
Publicado: (2017)

Antileukemic activity of novel adenosine derivatives
por: Poczta, Anastazja, et al.
Publicado: (2019)

The cyclohexene derivative MC-3129 exhibits antileukemic activity via RhoA/ROCK1/PTEN/PI3K/Akt pathway-mediated mitochondrial translocation of cofilin
por: Zheng, Yi, et al.
Publicado: (2018)

Cisplatin in combination with Phenethyl Isothiocyanate (PEITC), a potential new therapeutic strategy for malignant pleural mesothelioma
por: Denis, Iza, et al.
Publicado: (2014)

Mechanistic Insights into Chemopreventive Effects of Phenethyl Isothiocyanate in N‐Nitrosobis(2‐oxopropyl)amine‐treated Hamsters
por: Nishikawa, Akiyoshi, et al.
Publicado: (1997)

Phenethyl Isothiocyanate Enhances the Cytotoxic Effects of PARP Inhibitors in High-Grade Serous Ovarian Cancer Cells
por: Jia, Yaxun, et al.
Publicado: (2022)

Signal transduction activated by the cancer chemopreventive isothiocyanates: cleavage of BID protein, tyrosine phosphorylation and activation of JNK
por: Xu, K, et al.
Publicado: (2001)

β-Phenethyl Isothiocyanate Induces Cell Death in Human Osteosarcoma through Altering Iron Metabolism, Disturbing the Redox Balance, and Activating the MAPK Signaling Pathway
por: Lv, Huanhuan, et al.
Publicado: (2020)

Mitochondrial structure alteration in human prostate cancer cells upon initial interaction with a chemopreventive agent phenethyl isothiocyanate
por: Xue, Chengsen, et al.
Publicado: (2014)

In vitro and in vivo neuroprotective effect of caffeic acid phenethyl ester
por: Akyol, Sumeyya, et al.
Publicado: (2015)

Breast cancer cell growth inhibition by phenethyl isothiocyanate is associated with down-regulation of oestrogen receptor-α36
por: Kang, Lianguo, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_bnc6ptb61d2odv88dq85sffov9