SMG1 and NIK regulate apoptosis induced by Smac mimetic compounds

Smac mimetic compounds (SMCs) are experimental small molecules that induce tumour necrosis factor alpha (TNFα)-dependent cancer cell death by targeting the inhibitor of apoptosis proteins. However, many cancer cell lines are resistant to SMC-mediated apoptosis despite the presence of TNFα. To add in...

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Detalles Bibliográficos
Autores principales: Cheung, H H, St Jean, M, Beug, S T, Lejmi-Mrad, R, LaCasse, E, Baird, S D, Stojdl, D F, Screaton, R A, Korneluk, R G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2011
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3122057/
https://www.ncbi.nlm.nih.gov/pubmed/21490678
http://dx.doi.org/10.1038/cddis.2011.25

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3122057/
https://www.ncbi.nlm.nih.gov/pubmed/21490678
http://dx.doi.org/10.1038/cddis.2011.25

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