Blockade of Hsp90 by 17AAG antagonizes MDMX and synergizes with Nutlin to induce p53-mediated apoptosis in solid tumors

Strategies to induce p53 activation in wtp53-retaining tumors carry high potential in cancer therapy. Nutlin, a potent highly selective MDM2 inhibitor, induces non-genotoxic p53 activation. Although Nutlin shows promise in promoting cell death in hematopoietic malignancies, a major roadblock is that...

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Detalles Bibliográficos
Autores principales: Vaseva, A V, Yallowitz, A R, Marchenko, N D, Xu, S, Moll, U M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2011
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3122118/
https://www.ncbi.nlm.nih.gov/pubmed/21562588
http://dx.doi.org/10.1038/cddis.2011.39

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3122118/
https://www.ncbi.nlm.nih.gov/pubmed/21562588
http://dx.doi.org/10.1038/cddis.2011.39

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