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PKCη promotes a proliferation to differentiation switch in keratinocytes via upregulation of p27(Kip1) mRNA through suppression of JNK/c-Jun signaling under stress conditions
To maintain epidermal homeostasis, the balance between keratinocyte proliferation and differentiation is tightly controlled. However, the molecular mechanisms underlying this balance remain unclear. In 3D organotypic coculture with mouse keratinocytes and fibroblasts, the thickness of stratified cel...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3122119/ https://www.ncbi.nlm.nih.gov/pubmed/21593789 http://dx.doi.org/10.1038/cddis.2011.40 |