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Assessment of genome integrity with array CGH in cattle transgenic cell lines produced by homologous recombination and somatic cell cloning

BACKGROUND: Transgenic cattle carrying multiple genomic modifications have been produced by serial rounds of somatic cell chromatin transfer (cloning) of sequentially genetically targeted somatic cells. However, cloning efficiency tends to decline with the increase of rounds of cloning. It is possib...

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Detalles Bibliográficos
Autores principales: Liu, George E, Hou, Yali, Robl, James M, Kuroiwa, Yoshimi, Wang, Zhongde
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3123262/
https://www.ncbi.nlm.nih.gov/pubmed/21605421
http://dx.doi.org/10.1186/2041-9414-2-6