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Intramuscular immunization of mice with live influenza virus is more immunogenic and offers greater protection than immunization with inactivated virus

BACKGROUND: Influenza virus continues to cause significant hospitalization rates in infants and young children. A 2-dose regime of trivalent inactivated vaccine is required to generate protective levels of hemagglutination inhibiting (HAI) antibodies. A vaccine preparation with enhanced immunogenici...

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Detalles Bibliográficos
Autores principales: Harris, Katie, Ream, Rebecca, Gao, Jin, Eichelberger, Maryna C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3123286/
https://www.ncbi.nlm.nih.gov/pubmed/21600020
http://dx.doi.org/10.1186/1743-422X-8-251