Modular bioreactor for primary human hepatocyte culture: Medium flow stimulates expression and activity of detoxification genes

Down-regulation of detoxification genes, notably cytochrome P450 (CYPs), in primary hepatocyte cultures is a long-standing and major concern. We evaluated the influence of medium flow in this model. Hepatocytes isolated from 12 different liver donors were cultured either in a multichamber modular bi...

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Detalles Bibliográficos
Autores principales: Vinci, Bruna, Duret, Cédric, Klieber, Sylvie, Gerbal-Chaloin, Sabine, Sa-Cunha, Antonio, Laporte, Sylvain, Suc, Bertrand, Maurel, Patrick, Ahluwalia, Arti, Daujat-Chavanieu, Martine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3123466/
https://www.ncbi.nlm.nih.gov/pubmed/21259441
http://dx.doi.org/10.1002/biot.201000326

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3123466/
https://www.ncbi.nlm.nih.gov/pubmed/21259441
http://dx.doi.org/10.1002/biot.201000326

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