Pml represses tumour progression through inhibition of mTOR

The promyelocytic leukaemia gene PML is a pleiotropic tumour suppressor. We have recently demonstrated that PML opposes mTOR-HIF1α-VEGF signalling in hypoxia. To determine the relevance of PML-mTOR antagonism in tumourigenesis, we have intercrossed Pml null mice with Tsc2 heterozygous mice, which de...

Descripción completa

Detalles Bibliográficos
Autores principales: Bernardi, Rosa, Papa, Antonella, Egia, Ainara, Coltella, Nadia, Teruya-Feldstein, Julie, Signoretti, Sabina, Pandolfi, Pier Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2011
Materias:
Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3123467/
https://www.ncbi.nlm.nih.gov/pubmed/21387562
http://dx.doi.org/10.1002/emmm.201100130

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3123467/
https://www.ncbi.nlm.nih.gov/pubmed/21387562
http://dx.doi.org/10.1002/emmm.201100130

Ejemplares similares