Intrinsic disorder mediates the diverse regulatory functions of the Cdk inhibitor p21

Traditionally, well-defined three-dimensional structure was thought to be essential for protein function. However, myriad biological functions are performed by highly dynamic, intrinsically disordered proteins (IDPs). IDPs often fold upon binding their biological targets and frequently exhibit “bind...

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Detalles Bibliográficos
Autores principales: Wang, Yuefeng, Fisher, John C., Mathew, Rose, Ou, Li, Otieno, Steve, Sublett, Jack, Xiao, Limin, Chen, Jianhan, Roussel, Martine F., Kriwacki, Richard W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3124363/
https://www.ncbi.nlm.nih.gov/pubmed/21358637
http://dx.doi.org/10.1038/nchembio.536

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3124363/
https://www.ncbi.nlm.nih.gov/pubmed/21358637
http://dx.doi.org/10.1038/nchembio.536

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