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Intrinsic disorder mediates the diverse regulatory functions of the Cdk inhibitor p21
Traditionally, well-defined three-dimensional structure was thought to be essential for protein function. However, myriad biological functions are performed by highly dynamic, intrinsically disordered proteins (IDPs). IDPs often fold upon binding their biological targets and frequently exhibit “bind...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3124363/ https://www.ncbi.nlm.nih.gov/pubmed/21358637 http://dx.doi.org/10.1038/nchembio.536 |