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Fisetin Lowers Methylglyoxal Dependent Protein Glycation and Limits the Complications of Diabetes
The elevated glycation of macromolecules by the reactive dicarbonyl and α-oxoaldehyde methylglyoxal (MG) has been associated with diabetes and its complications. We have identified a rare flavone, fisetin, which increases the level and activity of glyoxalase 1, the enzyme required for the removal of...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3124487/ https://www.ncbi.nlm.nih.gov/pubmed/21738623 http://dx.doi.org/10.1371/journal.pone.0021226 |