Regulation of LRRK2 Expression Points to a Functional Role in Human Monocyte Maturation

Genetic variants of Leucine-Rich Repeat Kinase 2 (LRRK2) are associated with a significantly enhanced risk for Parkinson disease, the second most common human neurodegenerative disorder. Despite major efforts, our understanding of LRRK2 biological function and regulation remains rudimentary. In the...

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Detalles Bibliográficos
Autores principales: Thévenet, Jonathan, Pescini Gobert, Rosanna, Hooft van Huijsduijnen, Robertus, Wiessner, Christoph, Sagot, Yves Jean
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3124520/
https://www.ncbi.nlm.nih.gov/pubmed/21738687
http://dx.doi.org/10.1371/journal.pone.0021519

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3124520/
https://www.ncbi.nlm.nih.gov/pubmed/21738687
http://dx.doi.org/10.1371/journal.pone.0021519

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