Chloroquine treatment of ARPE-19 cells leads to lysosome dilation and intracellular lipid accumulation: possible implications of lysosomal dysfunction in macular degeneration

BACKGROUND: Age-related macular degeneration (AMD) is the leading cause of vision loss in elderly people over 60. The pathogenesis is still unclear. It has been suggested that lysosomal stress may lead to drusen formation, a biomarker of AMD. In this study, ARPE-19 cells were treated with chloroquin...

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Detalles Bibliográficos
Autores principales: Chen, Patrick M, Gombart, Zoë J, Chen, Jeff W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3125200/
https://www.ncbi.nlm.nih.gov/pubmed/21711726
http://dx.doi.org/10.1186/2045-3701-1-10

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3125200/
https://www.ncbi.nlm.nih.gov/pubmed/21711726
http://dx.doi.org/10.1186/2045-3701-1-10

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