Tissue inhibitor of metalloproteinase 1 (TIMP-1) deficiency exacerbates carbon tetrachloride-induced liver injury and fibrosis in mice: involvement of hepatocyte STAT3 in TIMP-1 production

BACKGROUND: Tissue inhibitor of metalloproteinase 1 (TIMP-1), which is thought to be produced mainly by activated hepatic stellate cells and Kupffer cells in the liver, plays a pivotal role in matrix remodeling during liver injury and repair; while the effect of TIMP-1 on hepatocellular damage remai...

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Detalles Bibliográficos
Autores principales: Wang, Hua, Lafdil, Fouad, Wang, Lei, Yin, Shi, Feng, Dechun, Gao, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3125204/
https://www.ncbi.nlm.nih.gov/pubmed/21711826
http://dx.doi.org/10.1186/2045-3701-1-14

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3125204/
https://www.ncbi.nlm.nih.gov/pubmed/21711826
http://dx.doi.org/10.1186/2045-3701-1-14

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