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Extracellular domain of CD98hc is required for early murine development

BACKGROUND: The multifunctional protein CD98 heavy chain (CD98hc, Slc3a2) associates with integrin β1 through its cytoplasmic and transmembrane domains and the CD98hc-mediated integrin signaling is required for maintenance of ES cell proliferation. CD98hc-null mice exhibit early post-implantation le...

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Detalles Bibliográficos
Autores principales: Sato, Yukiyasu, Heimeier, Rachel A, Li, Cuiling, Deng, Chuxia, Shi, Yun-Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3125211/
https://www.ncbi.nlm.nih.gov/pubmed/21711689
http://dx.doi.org/10.1186/2045-3701-1-7