Crystal Structures of Histone and p53 Methyltransferase SmyD2 Reveal a Conformational Flexibility of the Autoinhibitory C-Terminal Domain

SmyD2 belongs to a new class of chromatin regulators that control gene expression in heart development and tumorigenesis. Besides methylation of histone H3 K4, SmyD2 can methylate non-histone targets including p53 and the retinoblastoma tumor suppressor. The methyltransferase activity of SmyD protei...

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Detalles Bibliográficos
Autores principales: Jiang, Yuanyuan, Sirinupong, Nualpun, Brunzelle, Joseph, Yang, Zhe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3125274/
https://www.ncbi.nlm.nih.gov/pubmed/21738746
http://dx.doi.org/10.1371/journal.pone.0021640

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3125274/
https://www.ncbi.nlm.nih.gov/pubmed/21738746
http://dx.doi.org/10.1371/journal.pone.0021640

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