Cargando…

Antiprogestin mifepristone inhibits the growth of cancer cells of reproductive and non-reproductive origin regardless of progesterone receptor expression

BACKGROUND: Mifepristone (MF) has been largely used in reproductive medicine due to its capacity to modulate the progesterone receptor (PR). The study of MF has been expanded to the field of oncology; yet it remains unclear whether the expression of PR is required for MF to act as an anti-cancer age...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tieszen, Chelsea R, Goyeneche, Alicia A, Brandhagen, BreeAnn N, Ortbahn, Casey T, Telleria, Carlos M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3125282/ https://www.ncbi.nlm.nih.gov/pubmed/21619605 http://dx.doi.org/10.1186/1471-2407-11-207

Ejemplares similares

Cytostasis and morphological changes induced by mifepristone in human metastatic cancer cells involve cytoskeletal filamentous actin reorganization and impairment of cell adhesion dynamics
por: Brandhagen, BreeAnn N, et al.
Publicado: (2013)

Advanced assessment of migration and invasion of cancer cells in response to mifepristone therapy using double fluorescence cytochemical labeling
por: Ritch, Sabrina J., et al.
Publicado: (2019)

Antiprogestins in gynecological diseases
por: Goyeneche, Alicia A, et al.
Publicado: (2015)

Resistance to cisplatin and paclitaxel does not affect the sensitivity of human ovarian cancer cells to antiprogestin-induced cytotoxicity
por: Gamarra-Luques, Carlos D, et al.
Publicado: (2014)

Growth inhibition induced by antiprogestins RU-38486, ORG-31710, and CDB-2914 in ovarian cancer cells involves inhibition of cyclin dependent kinase 2
por: Goyeneche, Alicia A., et al.
Publicado: (2011)

Mifepristone prevents repopulation of ovarian cancer cells escaping cisplatin-paclitaxel therapy
por: Goyeneche, Alicia A, et al.
Publicado: (2012)

Mifepristone inhibits non-small cell lung carcinoma cellular escape from DNA damaging cisplatin
por: Kapperman, Heather E., et al.
Publicado: (2018)

Anticancer effects of mifepristone on human uveal melanoma cells
por: Alvarez, Prisca Bustamante, et al.
Publicado: (2021)

Resistance to cisplatin does not affect sensitivity of human ovarian cancer cell lines to mifepristone cytotoxicity
por: Freeburg, Elizabeth M, et al.
Publicado: (2009)

The metastatic capacity of high-grade serous ovarian cancer cells changes along disease progression: inhibition by mifepristone
por: Ritch, Sabrina J., et al.
Publicado: (2022)

New Generation of Meso and Antiprogestins (SPRMs) into the Osteoporosis Approach
por: Woźniczka, Magdalena, et al.
Publicado: (2021)

Synergistic Lethality of Mifepristone and LY294002 in Ovarian Cancer Cells
por: Wempe, Stacy L., et al.
Publicado: (2013)

Phase I study of onapristone, a type I antiprogestin, in female patients with previously treated recurrent or metastatic progesterone receptor-expressing cancers
por: Cottu, Paul H., et al.
Publicado: (2018)

Mifepristone Antagonization with Progesterone to Avert Medication Abortion: A Scoping Review
por: DeBeasi, Paul L. C.
Publicado: (2023)

Exogenous estradiol enhances apoptosis in regressing post-partum rat corpora lutea possibly mediated by prolactin
por: Goyeneche, Alicia A, et al.
Publicado: (2005)

X-Ray Crystal Structure of the Ancestral 3-Ketosteroid Receptor–Progesterone–Mifepristone Complex Shows Mifepristone Bound at the Coactivator Binding Interface
por: Colucci, Jennifer K., et al.
Publicado: (2013)

Antiprogestins reduce epigenetic field cancerization in breast tissue of young healthy women
por: Bartlett, Thomas E., et al.
Publicado: (2022)

Correction: Antiprogestins reduce epigenetic field cancerization in breast tissue of young healthy women
por: Bartlett, Thomas E., et al.
Publicado: (2022)

The efficacy and influence factors analysis of Mifepristone combined with estrogen-progesterone in the treatment of incomplete abortion
por: Wang, Kai, et al.
Publicado: (2022)

Characterization of Membrane-Associated Progesterone Receptor Component-2 (MAPRC2) from Trichinella spiralis and Its Interaction with Progesterone and Mifepristone
por: Aleem, Muhammad Tahir, et al.
Publicado: (2021)

Progesterone-mediated reversal of mifepristone-induced pregnancy termination in a rat model: an exploratory investigation
por: Camilleri, Christina, et al.
Publicado: (2023)

Novel RU486 (mifepristone) analogues with increased activity against Venezuelan Equine Encephalitis Virus but reduced progesterone receptor antagonistic activity
por: DeBono, Aaron, et al.
Publicado: (2019)

Microscopic Colitis and Reproductive Factors Related to Exposure to Estrogens and Progesterone
por: Roth, Bodil, et al.
Publicado: (2013)

Long-term primary culture of a clear cell ovarian carcinoma reveals an epithelial–mesenchymal cooperative interaction
por: Goyeneche, Alicia A., et al.
Publicado: (2015)

The progesterone antagonist mifepristone/RU486 blocks the negative effect on life span caused by mating in female Drosophila
por: Landis, Gary N., et al.
Publicado: (2015)

High-Grade Serous Ovarian Cancer: Basic Sciences, Clinical and Therapeutic Standpoints
por: Lisio, Michael-Antony, et al.
Publicado: (2019)

Mifepristone-Induced Hypothyroidism
por: Kalara, Niketa, et al.
Publicado: (2023)

Progesterone administration for luteal phase deficiency in human reproduction: an old or new issue?
por: Palomba, Stefano, et al.
Publicado: (2015)

Beyond reproduction: the role of progesterone in neuropathic pain after spinal cord injury
por: González, Susana Laura, et al.
Publicado: (2016)

Comparison of progesterone assay by chemiluminescence or radioimmunoassay for clinical decision-making in canine reproduction
por: Nöthling, Johan O., et al.
Publicado: (2019)

Beneficial Effects of Mifepristone Treatment in Patients with Breast Cancer Selected by the Progesterone Receptor Isoform Ratio: Results from the MIPRA Trial
por: Elía, Andrés, et al.
Publicado: (2023)

Regulation by Gonadal Steroids of Estrogen and Progesterone Receptors Along the Reproductive Tract in Female Lambs
por: Meikle, A, et al.
Publicado: (2001)

The impact of high progesterone levels on the day of HCG administration in assisted human reproduction treatments
por: Tanada, Michelli S, et al.
Publicado: (2018)

The Modified Bushen Antai Recipe Upregulates Estrogen and Progesterone Receptors at the Maternal-Fetal Interface in Pregnant Rats with Mifepristone-Induced Pregnancy Loss
por: Sun, Li, et al.
Publicado: (2019)

A Tangled Web: Origins of Reproductive Parasitism
por: Gillespie, Joseph J, et al.
Publicado: (2018)

“Regardless, you are not the first woman”: an illustrative case study of contextual risk factors impacting sexual and reproductive health and rights in Nicaragua
por: Luffy, Samantha M., et al.
Publicado: (2019)

Expression of progesterone receptor membrane component-1 in bovine reproductive system during estrous cycle
por: Luciano, A.M., et al.
Publicado: (2011)

Luteal Phase Support in assisted reproductive technology treatment: focus on Endometrin® (progesterone) vaginal insert
por: Check, Jerome H
Publicado: (2009)

Changes in the Transcriptome of the Human Endometrial Ishikawa Cancer Cell Line Induced by Estrogen, Progesterone, Tamoxifen, and Mifepristone (RU486) as Detected by RNA-Sequencing
por: Tamm-Rosenstein, Karin, et al.
Publicado: (2013)

Mifepristone modulates serotonin transporter function
por: Li, Chaokun, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_lqen8cnsecsr2bu1r5rh7i8ejq