Nitric oxide/cGMP pathway signaling actively down-regulates α(4)β(1)-integrin affinity: an unexpected mechanism for inducing cell de-adhesion

BACKGROUND: Integrin activation in response to inside-out signaling serves as the basis for rapid leukocyte arrest on endothelium, migration, and mobilization of immune cells. Integrin-dependent adhesion is controlled by the conformational state of the molecule, which is regulated by seven-transmemb...

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Detalles Bibliográficos
Autores principales: Chigaev, Alexandre, Smagley, Yelena, Sklar, Larry A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3125286/
https://www.ncbi.nlm.nih.gov/pubmed/21586157
http://dx.doi.org/10.1186/1471-2172-12-28

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3125286/
https://www.ncbi.nlm.nih.gov/pubmed/21586157
http://dx.doi.org/10.1186/1471-2172-12-28

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