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Nitric oxide/cGMP pathway signaling actively down-regulates α(4)β(1)-integrin affinity: an unexpected mechanism for inducing cell de-adhesion
BACKGROUND: Integrin activation in response to inside-out signaling serves as the basis for rapid leukocyte arrest on endothelium, migration, and mobilization of immune cells. Integrin-dependent adhesion is controlled by the conformational state of the molecule, which is regulated by seven-transmemb...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2011
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3125286/ https://www.ncbi.nlm.nih.gov/pubmed/21586157 http://dx.doi.org/10.1186/1471-2172-12-28 |