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Mechanism of the mitogenic influence of hyperinsulinemia
Either endogenous or exogenous hyperinsulinemia in the setting of insulin resistance promotes phosphorylation and activation of farnesyltransferase, a ubiquitous enzyme that farnesylates Ras protein. Increased availability of farnesylated Ras at the plasma membrane enhances mitogenic responsiveness...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2011
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3125332/ https://www.ncbi.nlm.nih.gov/pubmed/21668983 http://dx.doi.org/10.1186/1758-5996-3-10 |