Memory B Cells and CD8+ Lymphocytes Do Not Control Seasonal Influenza A Virus Replication after Homologous Re-Challenge of Rhesus Macaques

This study sought to define the role of memory lymphocytes in the protection from homologous influenza A virus re-challenge in rhesus macaques. Depleting monoclonal antibodies (mAb) were administered to the animals prior to their second experimental inoculation with a human seasonal influenza A viru...

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Detalles Bibliográficos
Autores principales: Carroll, Timothy D., Matzinger, Shannon R., Fritts, Linda, McChesney, Michael B., Miller, Christopher J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3126839/
https://www.ncbi.nlm.nih.gov/pubmed/21747924
http://dx.doi.org/10.1371/journal.pone.0021756
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author Carroll, Timothy D.
Matzinger, Shannon R.
Fritts, Linda
McChesney, Michael B.
Miller, Christopher J.
author_facet Carroll, Timothy D.
Matzinger, Shannon R.
Fritts, Linda
McChesney, Michael B.
Miller, Christopher J.
author_sort Carroll, Timothy D.
collection PubMed
description This study sought to define the role of memory lymphocytes in the protection from homologous influenza A virus re-challenge in rhesus macaques. Depleting monoclonal antibodies (mAb) were administered to the animals prior to their second experimental inoculation with a human seasonal influenza A virus strain. Treatment with either anti-CD8α or anti-CD20 mAbs prior to re-challenge had minimal effect on influenza A virus replication. Thus, in non-human primates with pre-existing anti-influenza A antibodies, memory B cells and CD8α(+) T cells do not contribute to the control of virus replication after re-challenge with a homologous strain of influenza A virus.
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spelling pubmed-31268392011-07-11 Memory B Cells and CD8+ Lymphocytes Do Not Control Seasonal Influenza A Virus Replication after Homologous Re-Challenge of Rhesus Macaques Carroll, Timothy D. Matzinger, Shannon R. Fritts, Linda McChesney, Michael B. Miller, Christopher J. PLoS One Research Article This study sought to define the role of memory lymphocytes in the protection from homologous influenza A virus re-challenge in rhesus macaques. Depleting monoclonal antibodies (mAb) were administered to the animals prior to their second experimental inoculation with a human seasonal influenza A virus strain. Treatment with either anti-CD8α or anti-CD20 mAbs prior to re-challenge had minimal effect on influenza A virus replication. Thus, in non-human primates with pre-existing anti-influenza A antibodies, memory B cells and CD8α(+) T cells do not contribute to the control of virus replication after re-challenge with a homologous strain of influenza A virus. Public Library of Science 2011-06-29 /pmc/articles/PMC3126839/ /pubmed/21747924 http://dx.doi.org/10.1371/journal.pone.0021756 Text en Carroll et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Carroll, Timothy D.
Matzinger, Shannon R.
Fritts, Linda
McChesney, Michael B.
Miller, Christopher J.
Memory B Cells and CD8+ Lymphocytes Do Not Control Seasonal Influenza A Virus Replication after Homologous Re-Challenge of Rhesus Macaques
title Memory B Cells and CD8+ Lymphocytes Do Not Control Seasonal Influenza A Virus Replication after Homologous Re-Challenge of Rhesus Macaques
title_full Memory B Cells and CD8+ Lymphocytes Do Not Control Seasonal Influenza A Virus Replication after Homologous Re-Challenge of Rhesus Macaques
title_fullStr Memory B Cells and CD8+ Lymphocytes Do Not Control Seasonal Influenza A Virus Replication after Homologous Re-Challenge of Rhesus Macaques
title_full_unstemmed Memory B Cells and CD8+ Lymphocytes Do Not Control Seasonal Influenza A Virus Replication after Homologous Re-Challenge of Rhesus Macaques
title_short Memory B Cells and CD8+ Lymphocytes Do Not Control Seasonal Influenza A Virus Replication after Homologous Re-Challenge of Rhesus Macaques
title_sort memory b cells and cd8+ lymphocytes do not control seasonal influenza a virus replication after homologous re-challenge of rhesus macaques
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3126839/
https://www.ncbi.nlm.nih.gov/pubmed/21747924
http://dx.doi.org/10.1371/journal.pone.0021756
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