Specific β-Tubulin Isotypes Can Functionally Enhance or Diminish Epothilone B Sensitivity in Non-Small Cell Lung Cancer Cells

Epothilones are a new class of microtubule stabilizing agents with promising preclinical and clinical activity. Their cellular target is β-tubulin and factors influencing intrinsic sensitivity to epothilones are not well understood. In this study, the functional significance of specific β-tubulin is...

Descripción completa

Detalles Bibliográficos
Autores principales: Gan, Pei Pei, McCarroll, Joshua A., Byrne, Frances L., Garner, James, Kavallaris, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3126859/
https://www.ncbi.nlm.nih.gov/pubmed/21738778
http://dx.doi.org/10.1371/journal.pone.0021717

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3126859/
https://www.ncbi.nlm.nih.gov/pubmed/21738778
http://dx.doi.org/10.1371/journal.pone.0021717

Ejemplares similares