The unfolded protein response is required to maintain the integrity of the endoplasmic reticulum, prevent oxidative stress and preserve differentiation in β-cells

Diabetes is an epidemic of worldwide proportions caused by β-cell failure. Nutrient fluctuations and insulin resistance drive β-cells to synthesize insulin beyond their capacity for protein folding and secretion and thereby activate the unfolded protein response (UPR), an adaptive signalling pathway...

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Detalles Bibliográficos
Autores principales: Kaufman, R J, Back, S H, Song, B, Han, J, Hassler, J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2010
Materias:
Review Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3127455/
https://www.ncbi.nlm.nih.gov/pubmed/21029306
http://dx.doi.org/10.1111/j.1463-1326.2010.01281.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3127455/
https://www.ncbi.nlm.nih.gov/pubmed/21029306
http://dx.doi.org/10.1111/j.1463-1326.2010.01281.x

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