A 5′-uridine amplifies miRNA/miRNA* asymmetry in Drosophila by promoting RNA-induced silencing complex formation

BACKGROUND: MicroRNA (miRNA) are diverse in sequence and have a single known sequence bias: they tend to start with uridine (U). RESULTS: Our analyses of fly, worm and mouse miRNA sequence data reveal that the 5′-U is recognized after miRNA production. Only one of the two strands can be assembled in...

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Detalles Bibliográficos
Autores principales: Seitz, Hervé, Tushir, Jogender S, Zamore, Phillip D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3127740/
https://www.ncbi.nlm.nih.gov/pubmed/21649885
http://dx.doi.org/10.1186/1758-907X-2-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3127740/
https://www.ncbi.nlm.nih.gov/pubmed/21649885
http://dx.doi.org/10.1186/1758-907X-2-4

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