Partially Glycosylated Dendrimers Block MD-2 and Prevent TLR4-MD-2-LPS Complex Mediated Cytokine Responses

The crystal structure of the TLR4-MD-2-LPS complex responsible for triggering powerful pro-inflammatory cytokine responses has recently become available. Central to cell surface complex formation is binding of lipopolysaccharide (LPS) to soluble MD-2. We have previously shown, in biologically based...

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Detalles Bibliográficos
Autores principales: Barata, Teresa S., Teo, Ian, Brocchini, Steve, Zloh, Mire, Shaunak, Sunil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3127813/
https://www.ncbi.nlm.nih.gov/pubmed/21738462
http://dx.doi.org/10.1371/journal.pcbi.1002095

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3127813/
https://www.ncbi.nlm.nih.gov/pubmed/21738462
http://dx.doi.org/10.1371/journal.pcbi.1002095

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