Overexpression of SIRT1 in Mouse Forebrain Impairs Lipid/Glucose Metabolism and Motor Function

SIRT1 plays crucial roles in glucose and lipid metabolism, and has various functions in different tissues including brain. The brain-specific SIRT1 knockout mice display defects in somatotropic signaling, memory and synaptic plasticity. And the female mice without SIRT1 in POMC neuron are more sensi...

Descripción completa

Detalles Bibliográficos
Autores principales: Wu, Dongmei, Qiu, Yifu, Gao, Xiang, Yuan, Xiao-Bing, Zhai, Qiwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3128079/
https://www.ncbi.nlm.nih.gov/pubmed/21738790
http://dx.doi.org/10.1371/journal.pone.0021759

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3128079/
https://www.ncbi.nlm.nih.gov/pubmed/21738790
http://dx.doi.org/10.1371/journal.pone.0021759

Ejemplares similares